Process systems engineering is a multidisciplinary area of research and development, which addresses the behavior of complex systems as a whole. Process systems engineering uses domain knowledge from engineering and computer sciences. The main scope of this research area includes computer-aided techniques for mathematical modeling, static and dynamic simulation, design and synthesis, control, monitoring, and optimization of general processes. The application area of process systems engineering is diverse, encompassing among others, biological systems, industrial processes, and energy generation systems. In particular, the Process Systems Engineering Group of CIFASIS conducts research activities in the following three major areas: Industrial Process Control and Monitoring: Plant-wide control and variable structure control, Fault-tolerant control, Industrial process monitoring and supervision, Integration between process design and control. Hybrid Generation Systems with Renewable Energy Sources and Hydrogen: Sizing, Energy management, Control-oriented dynamic modeling, System control. Optimal Operation of Industrial Processes: Real-time optimization of industrial processes, Integration with model predictive control, Optimizing control The main objectives of the group are contributing with new methodologies to systematize the decision making process in industrial plants and promoting the integration of the research areas mentioned above in order to obtain outstanding solutions for ensuring operability, safety and profitability of industrial processes.